An elaborate altarpiece in the Cathedral of Santo Domingo in colonial Santo Domingo, Dominican Republic. It depicts the Virgin Mary with Queen Isabela & King Ferdinand of Spain. Given as a gift in 1778. The Cathedral of Santa Maria La Menor was the first cathedral built in the Americas, completed about 1540 A.D. It is a Minor Basilica and is located in the old Colonial City of Santo Domingo. UNESCO World Heritage Site of the Colonial City of Santo Domingo.